Polymorphism of the IL-10 gene in Azeri population of Iran

Abstract Background Interleukin (IL)-10 is one of the key interleukins in immune system. It plays an anti-inflammatory role body by inhibition synthesis pro-inflammatory cytokines and reducing expression major histocompatibility complex II molecules. The single-nucleotide polymorphism gene this interleukin affects its level. Thus, study was conducted to investigate IL-10 at position -1082A/G Azeri population Iran. Methods Blood samples were taken from 254 healthy non-relevant Iranian individuals. After DNA extraction, frequency genotypes alleles determined allele specific-PCR method. Then, q-square test used compare frequencies with other populations, p value < 0.05 considered significant. Results In population, percentage AA, AG GG location 37.4, 43.3 19.3%, respectively. A G also 59.1 40.9%, Based on statistical analysis, current very similar Saudi Arabia, but it had a significant difference East Asia Ireland populations. Conclusion present indicate genotype neighbor ethnicities Middle country. patients backgrounds mentioned their questioners, associated susceptibility asthma Alzheimer which are common region.